Saikat Basu

Saikat Basu

Associate Professor and Graduate Program Coordinator

Biography

Dr. Saikat Basu directs the Biomedical and Bioinspired Fluid Dynamics Lab at ÈÕ±¾avÊÓÆµ. With a scholarly background in classical fluid mechanics, the group specializes in developing theoretical and computational fluid dynamics models of transport inside complex biophysical systems, with focus on respiratory physiology and tissue microenvironment.

To validate the models, the group collaborates with peers in experimental mechanics. The partnerships are often supplemented by tabletop experiments performed within 3D-printed anatomical replicas by Basu's team. For translational end goals, the group pursues cross-disciplinary collaborations with groups from medical science, nursing, biology, pharmacology, virology, immunology and the relevant industrial sectors (e.g., in drug delivery, personalized health care, medical device design and on modeling of respiratory infection transmission).

Basu has secured approximately $1.48 million in research funding from intramural and extramural sources, including a National Science Foundation CAREER Award and a National Institutes of Health Centers of Biomedical Research Excellence RPL Award. In 2024, he was also recognized with the Rising Star of Mechanical Engineering honor from the American Society of Mechanical Engineers.

Education

  • B.E. in civil engineering | Jadavpur University, India | 2009
  • Ph.D. in engineering mechanics | Virgina Tech | 2014

Academic and Professional Experience

Academic Interests
  • Theoretical and computational fluid dynamics
Academic Responsibilities
  • Engineering Mechanics in Biomedical Applications (ME 446/546, ÈÕ±¾avÊÓÆµ)
  • Mechanical Design Technologies (ME 212, ÈÕ±¾avÊÓÆµ)
  • Graduate Seminar (ME 790, ÈÕ±¾avÊÓÆµ)
  • Skeletal Biomechanics (fall 2018, UNC Chapel Hill)
  • Statics (fall 2017, UNC Chapel Hill)
  • Nonlinear Dynamics (spring 2016, OIST Japan)
  • Statics (spring 2014, Virginia Tech)
  • Fluid Mechanics I, II (summer 2012, Virginia Tech)
Committees and Professional Memberships

Committees

  • Member, ÈÕ±¾avÊÓÆµ Graduate Advisory Council, 2025-present
  • Chair, ÈÕ±¾avÊÓÆµ Mechanical Engineering Ph.D. Qualifying Examinations Committee, 2025-present
  • Member, ÈÕ±¾avÊÓÆµ College of Engineering Research Council, 2023-present
  • Member, ÈÕ±¾avÊÓÆµ Mechanical Engineering Faculty Search Committee, 2022-present
  • Member, National Institutes of Health Grant Review Panels, 2022-present
  • Faculty adviser, Biomedical Engineering Society Chapter at ÈÕ±¾avÊÓÆµ, 2022-present
  • Member, National Science Foundation Grant Review Panels, 2020-present
  • Member, ÈÕ±¾avÊÓÆµ Faculty Senate, 2019-2020
  • Chair, UNC Chapel Hill Smithies Nobel Symposium Planning Subcommittee, 2017

Professional Memberships

  • American Physical Society
  • Biomedical Engineering Society
  • International Society for Aerosols in Medicine
Work Experience
  • 2025-present, associate professor, tenured, ÈÕ±¾avÊÓÆµ
  • 2019-2025, assistant professor, tenure track, ÈÕ±¾avÊÓÆµ
  • 2017-2018, adjunct faculty, UNC/North Carolina State University
  • 2016-2018, postdoctoral fellow, University of North Carolina at Chapel Hill
  • 2014-2016, postdoctoral scholar, Okinawa Institute of Science and Technology, Japan
  • 2009-2014, graduate assistant, Virginia Tech
  • 2008, summer intern, DLR, Braunschweig, Germany

Research and Scholarly Work

Areas of Research

Bridging the engineering-medicine disconnect through discoveries and extensions from classical fluid mechanics and biomathematical modeling — with core contributions in areas of airborne transmission of diseases through respiratory routes and in the physics of tissue microenvironment.

Awards and Honors
  • 2025, Lohr Outstanding Faculty, Jerome J. Lohr College of Engineering, ÈÕ±¾avÊÓÆµ
  • 2024, ASME Rising Star of Mechanical Engineering
  • 2024, CAREER Award, National Science Foundation
  • 2024, Outstanding Researcher Award, Jerome J. Lohr College of Engineering, ÈÕ±¾avÊÓÆµ
  • 2024, Faculty Award for International Research, Office of International Affairs, ÈÕ±¾avÊÓÆµ
  • 2023, Research Project Leaders Award, National Institutes of Health – Centers of Biomedical Research Excellence
  • 2023, Grantswinship Award, Jerome J. Lohr College of Engineering, ÈÕ±¾avÊÓÆµ
  • 2023, Early Career Investigator of the Year, Jerome J. Lohr College of Engineering, ÈÕ±¾avÊÓÆµ
  • 2018, Fluid Dynamics Research Prize, Japan Society of Fluid Mechanics
  • 2015, Nomination for Outstanding Doctoral Dissertation, Virgina Tech
  • 2013, Paul Torgersen Research Excellence Award
  • 2010, Bechtel Travel Fellowship, Virginia Tech
  • 2009, Pratt Presidential Graduate Fellowship, Virginia Tech
  • 2008, Summer Fellowship, IASc India
  • 2007, Summer Fellowship, JNCASR India
  • 2004, National Merit Scholarship Certificate, India
Grants
  • The Contagion Science: Integration of inhaled transport mechanics principles inside the human upper respiratory tract at multi scales. NSF CAREER Award, January 2024-December 2028, $540,428.
  • CAREER supplement: The Contagion Science: Integration of inhaled transport mechanics principles inside the human upper respiratory tract at multi scales. NSF Supplemental Award for Travel (an NSF-European Research Council Mechanism), January 2024-December 2028, $17,058.
  • Computational and theoretical fluid mechanics modeling for transport in dense tumors. NIH COBRE Research Project Leader Grant, March 2023, February 2026, $450,000.
  • Sponsored collaboration with Aptar Pharma: Designing targeted carrier solutions for intranasal vaccines. Industry-sponsored project, August 2022-May 2024, $66,066.
  • Collaborative Research: New Generation of a Bio-inspired Protective Mask Based on Thermal and Vortex Traps. NSF CBET RAPID Grant, May 2020-April 2022, $62,824.
  • Computational tracking of perfusion in solid tumors. NIH COBRE Pilot Grant, April 2021-July 2022, $49,999.
  • Improving topical drug delivery for treatment of chronic rhinosinusitis using CFD, NIH R01 Subcontract from University of North Carolina-Chapel Hill, April 2019-May 2020, $20,021.
  • Development of a digital platform to assess targeted regional drug delivery for airway sites. Haarberg Drug, Disease and Delivery (3D Center) Center Exploratory Grant, April 2023-June 2024, $99,710.
  • "Peak band" vs. "Monotonic decay": exploring particle deposition and penetration in anatomic cavities. Haarberg 3D Center Award for Undergraduate Research Support, February 2023-June 2023, $3,000.
  • Use of CFD to track respiratory transport in the throat. Scholarly Dissemination Award from ÈÕ±¾avÊÓÆµ Office of Academic Affairs, November 2019-May 2020, $500.
  • CFD-based identification of optimal particle sizes for targeted drug delivery at laryngeal granulomas. NIH NCATS Pilot Grant 2KR971701 awarded through UNC-CH, February 2018-May 2019, $2,000.
Publications
  1. Md Tariqul Hossain, A. Malakar, M. Yeasin, M.M.H. Akash, A.A.T. Borojeni, D. Samanta, G. Williams, J. Reineke, G. Farias, S. Jung, J. Suman, S. Basu. Mechanics-guided parametric modeling of intranasal spray devices and formulations for targeted drug delivery to the nasopharynx. Frontiers in Drug Delivery, Sec. Technological and Methodological Advances in Drug Delivery, in press, November 2025.
  2. A. Chakravarty, S. Basu, M.V. Panchagnula, N.A. Patankar. Editorial: Translating biomechanics of the human airways for classification, diagnosis and treatment of pulmonary diseases. Frontiers in Physiology, Sec. Respiratory Physiology and Pathophysiology, in press, November 2025.
  3. M. Singh, S. Basu, D. Samanta. Effect of substrate flexibility on Non-Newtonian droplet impact dynamics on flexible superhydrophobic surfaces. Journal of Colloid and Interface Science, 704(2), 2026.
  4. S. Basu. On the mechanics of inhaled bronchial transmission of pathogenic microdroplets generated from the upper respiratory tract, with implications for infection onset. PLOS One, Vol. 20(10), 2025.
  5. A.B. Merife, A. Poudel, A. Polshchikova, Z.L. Geffert, J. Horton, M.M.H. Akash, A. Pandey, S. Basu, D. Fougnier, P. Soman. 3D osteocyte networks under pulsatile unidirectional fluid flow stimuli (PUFFS). ACS Biomaterials Science and Engineering, Vol. 11(10), 2025.
  6. M. Singh, S. Basu and D. Samanta. Non-Newtonian fluid droplet impact dynamics on thin liquid films. Physics of Fluids, Vol. 37(2), 022139, 2025.
  7. Z. Wu, S. Basu, S. Kim, M. Sorrells, F.J. Beron-Vera and S. Jung. Coherent spore dispersion via drop-leaf interactions. Science Advances, Vol. 10(5), eadj8092, 2024.
  8. M.M.H. Akash, Y. Lao, P.A. Balivada, P. Ato, N.K. Ka, A. Mituniewicz, Z. Silfen, J. Suman, A. Chakravarty, D. Joseph-McCarthy and S. Basu. On a model-based approach to improve intranasal spray targeting for respiratory viral infections. Frontiers in Drug Delivery, Sec. Respiratory Drug Delivery, Vol. 3, 1164671, 2023.
  9. M.M.H. Akash, N. Chakraborty, J. Mohmmad, K. Reindl and S. Basu. Computational multiphase characterization of perfusion trends inside biomimetic reduced-order dense tumors. Experimental and Computational Multiphase Flow, Vol. 5(3), 319-329, 2023.
  10. J. Yuk, M.M.H. Akash, A. Chakraborty, S. Basu, L.P. Chamorro and S. Jung. Morphology of pig nasal structure and modulation of airflow, thermal conditioning and olfactory functionality. Integrative and Comparative Biology, Vol. 63(2), 304-314, 2023.
  11. D.V. Egeren, M. Stoddard, A. Malakar, D. Ghosh, A. Acharya, S. Mainuddin, B. Majumdar, D. Luo, R. Nolan, D. Joseph-McCarthy, L.F. White, N.S. Hochberg, S. Basu and A. Chakravarty. No magic bullet: Limiting in-school transmission in the face of variable SARS-CoV-2 viral loads. Frontiers in Public Health, Sec. Infectious Diseases: Epidemiology and Prevention, Vol. 10, 941773, 2022.
  12. S. Basu, U.A. Khwaja, S.A.A. Rizvi, M.A. Sanchez-Gonzalez and G. Ferrer. Evaluation of patient experience for a computationally-guided intranasal spray protocol to augment therapeutic penetration: Implications for effective treatments for COVID-19, rhinitis and sinusitis. Medical Research Archives, Vol. 10(4), 2022.
  13. J. Yuk, A. Chakraborty, S. Cheng, C.I. Chung, A. Jorgensen, S. Basu*, L.P. Chamorro* and S. Jung*. On the design of particle filters inspired by animal noses. Journal of the Royal Society Interface, Vol. 19(188), 20210849 | * all corresponding authors, 2022.
  14. S. Basu, M.M.H. Akash, N.S. Hochberg, B.A. Senior, D. Joseph-McCarthy and A. Chakravarty. From SARS-CoV-2 infection to COVID-19 morbidity: An in silico projection of virion flow rates to the lower airway via nasopharyngeal fluid boluses. Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Vol. 5(5), 10-18, 2022.
  15. S. Basu. Computational characterization of inhaled droplet transport to the nasopharynx. Scientific Reports (open-access, peer-reviewed journal from Nature), Vol. 11(1), 6652, 2021.
  16. M.A. Stremler, S. Basu and E. Masroor. Streamline patterns in 2P vortex street equilibria. Journal of Fluid Mechanics, Vol. 901 E2, 1-4, 2020.
  17. S. Basu, L.T. Holbrook, K. Kudlaty, O. Fasanmade, J. Wu, A. Burke, B.W. Langworthy, M. Mamdani, Z. Farzal, W.D. Bennett, J.P. Fine, B.A. Senior, A.M. Zanation, C.S. Ebert Jr., A. Kimple, B. Thorp, D.O. Frank-Ito, G.J.M. Garcia and J.S. Kimbell. Numerical evaluation of spray position for improved nasal drug delivery. Scientific Reports (open-access, peer-reviewed journal from Nature), Vol. 10(1), 10568, 2020.
  18. S. Treat, C.S. Ebert Jr., Z. Farzal, S. Basu, A.M. Zanation, B.D. Thorp, J.S. Kimbell, B.A. Senior and A.J. Kimple. Intranasal corticosteroids: Patient administration angles and impact of education. Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Vol. 3, 160-166, 2020.
  19. B.M. Brandon, W.H. Stepp, S. Basu, J.S. Kimbell, B.A. Senior, W.W. Shockley and J. Madison Clark. Nasal airflow changes with bioabsorbable implant, butterfly and spreader grafts. The Laryngoscope, Vol. 130(12), E817-E823, 2020.
  20. Z. Farzal, S. Basu, A. Burke, O. Fasanmade, E. Mamuyac, W. Bennett, C.S. Ebert Jr., A. Zanation, B.A. Senior and J.S. Kimbell. Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients. International Forum of Allergy and Rhinology, Vol. 9(7), 746-758, 2019.
  21. L.F. Tracy, S. Basu, P. Shah, D.O. Frank-Ito, S. Das, A. Zanation and J.S. Kimbell. Impact of endoscopic craniofacial resection on simulated nasal airflow and heat transport. International Forum of Allergy and Rhinology, Vol. 9(8), 900-909, 2019
  22. J.S. Kimbell, S. Basu, G.J.M. Garcia, D.O. Frank-Ito, F.B. Lazarow, E. Su, D.E. Protsenko, Z. Chen, J. Rhee and B.J. Wong. Upper airway reconstruction using anatomic optical coherence tomography: Effects of airway bend on airflow resistance. Lasers in Surgery and Medicine, Vol. 51(2), 150-160, 2019.
  23. S. Basu, D.O. Frank-Ito and J.S. Kimbell. On computational fluid dynamics models for sinonasal drug transport: Relevance of nozzle subtraction and nasal vestibular dilation. International Journal for Numerical Methods in Biomedical Engineering, Vol. 34(4), e2946, 2018.
  24. E. Perkins, S. Basu, G.J.M. Garcia, R. Buckmire, R. Shah and J.S. Kimbell. Ideal particle sizes for inhaled steroids targeting vocal granulomas: Preliminary study using computational fluid dynamics. Otolaryngology – Head and Neck Surgery, Vol. 158(3), 511-519, 2018.
  25. B.M. Brandon, G.K. Austin, G. Fleischman, S. Basu, J.S. Kimbell, W.D. Shockley and J. Madison Clark. Comparison of airflow between spreader and butterfly grafts using computational fluid dynamics in cadaveric models. JAMA Facial Plastic Surgery, Vol. 20(3), 215-221, 2018.
  26. J.S. Kimbell, S. Basu, Z. Farzal and B.A. Senior. Characterizing nasal delivery in 3D models before and after sinus surgery. Respiratory Drug Delivery, Vol. 1, 181-188, 2018.
  27. S. Basu, A. Yawar, A. Concha and M.M. Bandi. On angled bounce-off impact of a drop impinging on a flowing soap film. Fluid Dynamics Research, Vol. 49(6), 065509, 2017 | Awarded Fluid Dynamics Research Prize 2018.
  28. S. Basu and M.A. Stremler. Exploring the dynamics of 2P wakes with reflective symmetry using point vortices. Journal of Fluid Mechanics, Vol. 831, 72-100, 2017.
  29. S. Basu and M.A. Stremler. On the motion of two point vortex pairs with wake-inspired glide-reflective symmetry in a periodic strip. Physics of Fluids, Vol. 27(10), 103603, 2015.
  30. M.A. Stremler and S. Basu. On point vortex models of exotic bluff body wakes. Fluid Dynamics Research, Vol. 46(6), 061410, 2014.
  31. M.A. Stremler, A. Salmanzadeh, S. Basu and C.H.K. Williamson. A mathematical model of 2P and 2C vortex wakes. Journal of Fluids and Structures, Vol. 27(5-6), 774-783, 2011.

CV

Mailing Address:
Crothers Engineering Hall 216
Mechanical Engineering-Box 2219
University Station
Brookings, SD 57007
Office Location:
Crothers Engineering Hall
Room 216
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